Antiulcerogenic Activity of 1-Hydroxy-3,7,8-trimethoxyxanthone Isolated from the Methanol Extract of Anthocleista vogelii PLANCH. in Rats

Table 1

Effect of the ten fractions of the methanol extract of  A. vogelii and 1-hydroxy 3,7,8-trimethoxyxanthone (AV) on HCl/ethanol-induced gastric lesions in rats.

Treatment	𝑛	Dose (mg/kg)	US area (mm²)	Ulcer index	% US	% I	Mucus weight (mg)
Distilled water	6	—	132.61 ± 24.70	5.49 ± 0.98	22.02	—	51.00 ± 0.46
Cimetidine	6	12	92.82 ± 16.62	5.57 ± 0.76	13.78	29.84	61.00 ± 0.83
Sucralfate	6	50	36.87 ± 25.14^b	3.46 ± 1.75	4.82	72.20	78.00 ± 0.96^b
	6	100	25.21 ± 4.26^b	3.72 ± 0.38^a	3.80	80.99	85.00 ± 1.20^b
𝐹1	6	100	50.21 ± 11.51^b	4.45 ± 0.74	6.11	61.51	100.00 ± 3.79^b
𝐹2	6	100	48.12 ± 11.04^b	3.89 ± 0.46^a	6.59	63.71	98.00 ± 4.62^b
𝐹3	6	100	22.27 ± 15.20^b	2.83 ± 1.39^b	3.18	83.21	116.00 ± 7.89^b
𝐹4	6	100	38.61 ± 16.82^b	3.07 ± 0.72^b	5.00	70.88	100.00 ± 4.59^b
𝐹5	6	100	44.73 ± 21.45^b	3.73 ± 0.42^b	5.71	66.27	95.00 ± 2.60^b
𝐹6	6	100	29.40 ± 14.37^b	3.09 ± 0.31^b	3.84	77.84	104.00 ± 5.62^b
𝐹7	6	100	101.65 ± 18.24	5.28 ± 0.77	1.46	23.35	65.00 ± 4.82
𝐹8	6	100	36.19 ± 17.05^b	3.52 ± 0.68^b	4.57	72.71	101.00 ± 7.20^b
𝐹9	6	100	18.43 ± 6.43^b	3.10 ± 0.63^b	2.47	86.10	106.00 ± 6.05^b
𝐹10	6	100	50.90 ± 17.50^b	3.58 ± 0.47^a	6.41	61.62	88.00 ± 4.39^b
AV	6	1	51.85 ± 4.83^b	4.87 ± 0.80	8.31	60.90	55.00 ± 0.56
AV	6	2	8.99 ± 5.77^b	2.32 ± 1.26^b	1.40	93.22	115.00 ± 2.21^b
AV	6	5	14.62 ± 1.27^b	2.86 ± 0.30^b	2.22	88.98	90.00 ± 1.13^b

𝑁 = number of rats per group.
I = inhibition.
US = ulcer surface.
^a𝑃≤0.05; ^b𝑃≤ 0.01 statistically significant relative to negative control (distilled water).