Antiulcerogenic Activity of 1-Hydroxy-3,7,8-trimethoxyxanthone Isolated from the Methanol Extract of Anthocleista vogelii PLANCH. in Rats

Table 2

Effects of 1-hydroxy-3,7,8-trimethoxyxanthone (AV) on gastric lesions induced by Indometacin in rat.

Treatment	𝑛	Dose (mg/kg)	US area (mm^2)	Ulcer index	% US	% I	Mucus weight (mg)
Distilled water	6	—	82.97 ± 5.08	3.64 ± 0.68	13.96	—	57 ± 0.64
Sucralfate	6	50	14.75 ± 3.39^b	3.16 ± 0.61	02.43	82.22	59 ± 0.40
AV	6	1	44.09 ± 8.86^b	3.00 ± 0.45^a	07.49	46.86	58 ± 0.35
AV	6	2	19.16 ± 5.36^b	2.83 ± 0.84^a	03.05	76.91	62 ± 0.72
AV	6	5	8.56 ± 5.64^b	1.38 ± 0.68^b	01.30	89.68	79 ± 1.00^b

𝑁= number of rats per group.
I = inhibition.
US = ulcer surface.
^a𝑃≤0.05; ^b𝑃≤0.01 statistically significant relative to negative control (distilled water).