Antiulcerogenic Activity of 1-Hydroxy-3,7,8-trimethoxyxanthone Isolated from the Methanol Extract of Anthocleista vogelii PLANCH. in Rats

Table 3

Effects of 1-hydroxy-3,7,8-trimethoxyxanthone (AV) on pylorus ligation ulceration.

Treatment	𝑛	Dose (mg/kg)	US area (mm^2)	Ulcer index	% US	% I	Gastric juice (mL)	Gastric PH	Gastric acidity (mEq/L)	Mucus weight (mg)
Distilled water	6	—	64.63 ± 5.24	3.91 ± 1.16	16.62	—	5.71 ± 0.71	1.83 ± 0.66	134.17 ± 2.04	56.00 ± 0.69
Cimetidine	6	12	41.45 ± 8.43^b	2.33 ± 0.34	06.52	35.87	5.53 ± 0.79	1.58 ± 0.93	89.95 ± 19.71^b	63.00 ± 0.60
Maalox	6	50	24.15 ± 2.88^b	2.72 ± 0.28	03.71	62.63	6.30 ± 0.63^b	0.97 ± 0.34^a	115.55 ± 26.13	64.00 ± 0.66
AV	6	1	68.34 ± 4.32	3.19 ± 0.41	12.21	0.00	4.51 ± 1.18	1.80 ± 1.03	118.55 ± 51.76	58.00 ± 0.66
AV	6	2	21.36 ± 4.19^b	2.59 ± 0.70	04.08	66.95	5.70 ± 1.88	1.08 ± 0.14^a	121.50 ± 30.50	79.00 ± 0.48^b
AV	6	5	18.94 ± 3.65^b	2.19 ± 0.70	03.44	70.69	4.88 ± 0.90	1.49 ± 0.54	96.93 ± 25.39^a	78.00 ± 0.40^b

𝑁= number of rats per group.
I = inhibition.
US = ulcer surface.
^a𝑃≤0.05; ^b𝑃≤0.01 statistically significant relative to negative control (distilled water).