Table of Contents
Ulcers
Volume 2014, Article ID 729754, 4 pages
http://dx.doi.org/10.1155/2014/729754
Research Article

Anti-Inflammatory and Gastroprotective Evaluation of Prodrugs of Piroxicam

R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, India

Received 28 June 2014; Accepted 13 August 2014; Published 26 August 2014

Academic Editor: Gyula Mozsik

Copyright © 2014 Vivekkumar K. Redasani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. L. Blower and C. P. Armstrong, “Perforated duodenal ulcers,” The British Journal of Surgery, vol. 74, no. 8, p. 759, 1987. View at Google Scholar · View at Scopus
  2. S. Pal, P. Bindu, P. K. Dubey, S. Chakraborty, and A. K. Mukherjee, “Synthesis and structure analysis of cyclodehydration product of piroxicam: a metabolite detected in dogs and monkeys,” European Journal of Medicinal Chemistry, vol. 44, no. 8, pp. 3368–3371, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. C. N. Aguwa, “Incidence of gastric ulcers by indomethacin and piroxicam in rats,” Archives of Toxicology, vol. 56, no. 3, pp. 212–213, 1984. View at Google Scholar · View at Scopus
  4. S. Kawai, F. Kojima, and N. Kusunoki, “Recent advances in nonsteroidal anti-inflammatory drugs,” Allergology International, vol. 54, no. 2, pp. 209–215, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. N. M. Nielsen and H. Bundgaard, “Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties,” Journal of Pharmaceutical Sciences, vol. 77, no. 4, pp. 285–298, 1988. View at Publisher · View at Google Scholar · View at Scopus
  6. T. J. Carty, A. Marfat, F. F. Moore, F. C. Falkner, T. M. Twomey, and A. Weissman, “Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam,” Agents and Actions, vol. 39, no. 3-4, pp. 157–165, 1993. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Jayaselli, J. M. S. Cheemala, D. P. Geetha Rani, and S. Pal, “Derivatization of enolic OH of piroxicam: a comparative study on esters and sulfonates,” Journal of the Brazilian Chemical Society, vol. 19, no. 3, pp. 509–515, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. F. Rafferty and G. Johnson, Morris Plains, N.J., 260/404, 4,689,182, Warner-Lambert Company, 1987.
  9. M. E. Godoy, A. Rotelli, L. Pelzer, and C. E. Tonn, “Antiinflammatory activity of cinnamic acid esters,” Molecules, vol. 5, no. 3, pp. 547–548, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. L. P. Zhang and Z. Z. Ji, “Synthesis, antiinflammatory and anticancer activity of cinnamic acids, their derivatives and analogues.,” Acta Pharmaceutica Sinica, vol. 27, no. 11, pp. 817–823, 1992. View at Google Scholar · View at Scopus
  11. H. Park, R. Kumareswaran, and T. V. RajanBabu, “Tunable phosphinite, phosphite and phosphoramidite ligands for the asymmetric hydrovinylation reactions,” Tetrahedron, vol. 61, no. 26, pp. 6352–6367, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. C. A. Winter, E. A. Risley, and G. W. Nuss, “Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs,” Proceedings of the Society for Experimental Biology and Medicine, vol. 111, pp. 544–547, 1962. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Cioli, S. Putzolu, V. Rossi, P. Scorza Barcellona, and C. Corradino, “The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats,” Toxicology and Applied Pharmacology, vol. 50, no. 2, pp. 283–289, 1979. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Mishra, R. Veerasamy, P. K. Jain, V. K. Dixit, and R. K. Agrawal, “Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac,” European Journal of Medicinal Chemistry, vol. 43, no. 11, pp. 2464–2472, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. V. K. Redasani and S. B. Bari, “Synthesis and evaluation of mutual prodrugs of ibuprofen with menthol, thymol and eugenol,” European Journal of Medicinal Chemistry, vol. 56, pp. 134–138, 2012. View at Publisher · View at Google Scholar · View at Scopus