Research Article

Mapping and Identification of the Urine Proteome of Prostate Cancer Patients by 2D PAGE/MS

Figure 3

Network associated with the 11 urinary proteins from patients with PCa according to IPA. Top protein network of functional associations between proteins was Cell Death and Survival, Cell-To-Cell Signaling and Interaction, and System Development and Function with score 30 (). The proteins are connected through four major nodes: ubiquitin (UBC) and cytokines, TNF, TGFB1, and IFNG. The proteins identified in this study are represented with gene names (for protein name, please see Table 3) and coloured in gray. The network is graphically displayed with proteins as nodes and the biological relationships between the nodes as lines. Different shapes represent the functional classes of proteins. The length of a line reflects published evidence supporting the node-to-node relationship concerned.
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