Dramatic Increase in Cerebral Blood Flow following Soman Intoxication If Signs of Symptoms Can Be Seen
Table 4
Vascular resistance (VR) presented as percent of baseline value (100%) in control rats (), rats intoxicated with Soman not showing signs of poisoning (), and rats showing signs of poisoning (). Values represent mean ± SEM.
Organ
Symptoms
−10 min
5 min
35 min
Brain
Control
100 ± 0
91 ± 5.0
94 ± 7.1
No signs
100 ± 0
91 ± 5.4
108 ± 13.3
Signs
100 ± 0
93 ± 6.4
51 ± 6.2
Diaphragm
Control
100 ± 0
123 ± 19.2
128 ± 13.2
No signs
100 ± 0
85 ± 9.2
96 ± 16.1
Signs
100 ± 0
92 ± 3.3
172 ± 33.4
Facial skin
Control
100 ± 0
87 ± 8.4
64 ± 11.2
No signs
100 ± 0
132 ± 8.5
248 ± 87.6
Signs
100 ± 0
194 ± 27.7
602 ± 212.4
Abdominal skin
Control
100 ± 0
95 ± 8.6
60 ± 6.5
No signs
100 ± 0
102 ± 8.0
151 ± 31.5
Signs
100 ± 0
133 ± 25.7
235 ± 50.0
Spleen
Control
100 ± 0
118 ± 26.1
62 ± 13.0
No signs
100 ± 0
115 ± 11.7
138 ± 19.1
Signs
100 ± 0
116 ± 16.0
1181 ± 442.8
Pancreas
Control
100 ± 0
99 ± 12.6
68 ± 11.3
No signs
100 ± 0
121 ± 7.1
138 ± 7.4
Signs
100 ± 0
141 ± 23.6
1212 ± 509.8
Kidney
Control
100 ± 0
101 ± 8.3
86 ± 6.4
No signs
100 ± 0
88 ± 10.9
93 ± 6.5
Signs
100 ± 0
91 ± 5.4
136 ± 17.3
Cardiac muscle
Control
100 ± 0
105 ± 13.6
104 ± 12.1
No signs
100 ± 0
92 ± 12.4
80 ± 18.5
Signs
100 ± 0
88 ± 6.8
41 ± 6.7
, paired comparisons from baseline value. , paired comparisons from baseline value.
