organophosph poison associ advers effect central nervous system seizur convuls activ long term chang neuron network this studi report investig design assess consequ soman high toxic organophosphorus compound exposur region blood flow rat brain peripher organ perform repeat blood flow measur same anim use microspher techniqu character chang region blood flow differ time after soman intox addit cardiopulmonari effect soman were follow dure intox administr soman 1 50 90 anaesthet rat produc decreas blood acetylcholinesteras activ all anim test although onli six out ten rat show sign poison like decreas respiratori rate result show onli anim signific sign poison demonstr increas cerebr blood flow conclud great import treat all data individu overal mean can easili misinterpret conceal import effect also conclud increas cerebr blood flow has import role effect respir effect independ blood acetylcholinesteras activ

Ann Göransson Nyberg

Gudrun E. Cassel

Dramatic Increase in Cerebral Blood Flow following Soman Intoxication If Signs of Symptoms Can Be Seen

background bacteri ribosom have been consid princip target tetracyclin recent new clinic data has shown how other biomacromolecul involv cellular damag bacteria research now reconsid pharmacolog classif tetracyclin onli base semisynthet synthet generat also follow new mechan action progress be discov materi method the toxic properti seven tetracyclin deriv tetracyclin oxytetracyclin demeclocyclin chlortetracyclin doxycyclin minocyclin meclocyclin were investig vitro use cell line human keratinocyt cell were irradi presenc tetracyclin differ durat three differ intens light the investig protein oxid set use model protein quantifi format carbonyl group result after incub irradi light viabil keratinocyt assess half maxim inhibitori concentr doxycyclin demeclocyclin chlortetracyclin tetracyclin phototox observ oxytetracyclin meclocyclin minocyclin conclus this studi provid evid tetracyclin deriv show differ photobehaviour accord chemic properti due differ reactiv group same molecular skeleton

Domenico Fuoco

Cytotoxicity Induced by Tetracyclines via Protein Photooxidation

oxidat stress mechan involv hepatotox the liver report affect bisphenol bpa anim studi has been also report possess hepat toxic this studi aim examin associ between liver health status effect bpa antioxid defens system liver biomark bpa 0 2 10 50 bodi weight mix corn oil intraperiton administ everi fortyeight hour 30 day dosedepend manner there signific differ between bodi weight weight rat liver bpatreat group control group the studi result show level malondialdehyd mda hydrogen peroxid 2 2 increas after exposur bpa howev antioxid enzym catalas cat superoxid dismutas sod glutathion peroxidas gshpx were signific resp decreas 50 dosag liver marker activ lactat dehydrogenas ldh glutamicoxalacet transaminas got glutamicpyruv transaminas gpt were signific increas while glutamyl transferas activ decreas bpa exposur increas activ liver biomark indic liver hyperact analysi liver section provid essenti evid liver apoptosi moreov bpa may lead induc toxic respons liver oxid system

Ansoumane Kourouma

Chao Quan

Peng Duan

Suqin Qi

Tingting Yu

Yinan Wang

Kedi Yang

Bisphenol A Induces Apoptosis in Liver Cells through Induction of ROS

system biolog synthet biolog emerg disciplin which becom increas utilis sever area bioscienc toxicolog begin benefit from system biolog suggest futur also benefit from synthet biolog thus new era horizon this review illustr how suit innov techniqu tool can appli understand complex health toxicolog issu review limit confront tradit comput approach toxicolog epidemiolog research use polycycl aromat hydrocarbon pahs effect advers birth outcom illustr exampl introduc how system toxicolog subdisciplin genom proteom metabolom toxicolog help overcom limit particular discuss advantag disadvantag mathemat framework comput repres biolog system final discuss nascent disciplin synthet biolog highlight relev toxicolog centr applic techniqu includ improv personalis medicin conclud review present number opportun challeng could shape futur rapid evolv disciplin

Mark T. Mc Auley

Hyunok Choi

Kathleen Mooney

Emily Paul

Veronica M. Miller

Systems Biology and Synthetic Biology: A New Epoch for Toxicology Research

this studi assess like health risk human contamin heavi metal from fish consumpt the analysi idea fish destin status fish area heavi metal determin assess it risk limit daili intak metal health risk index variat accumul heavi metal concentr were between various tissu organ skin muscl gill liver intestin kidney brain bone across batch two fish origin post hoc duncan multicomparison show signific differ across batch the concentr heavi metal analyz investig tissu scomber scombrus show higher level heavi metal accumul order were abov recommend safeti limit outlin fao who howev consum health risk consumpt fish muscl tissu show greater tendenc cadmium lead mercuri exposur also consumpt scomber scombrus speci abov recommend daili intak state studi might lead ingest heavi metal unaccept concentr

Abdullahi Abubakar

Adamu Uzairu

Patricia Adamma Ekwumemgbo

Oluwole Joshua Okunola

Risk Assessment of Heavy Metals in Imported Frozen Fish <i>Scomber scombrus</i> Species Sold in Nigeria: A Case Study in Zaria Metropolis

levofloxacin lfx broad spectrum fluoroquinolon antibiot use treatment infect pneumonia chronic bronchiti sinus the present studi assess like toxic effect lfx hepat renal tissu rat twenti male wistar rat were random divid four treatment group control 5 lfx half therapeut dose 10 lfx therapeut dose 20 lfx doubl therapeut dose after seven day administr result indic signific increas plasma alt ast alp activ treat group compar control also signific increas plasma creatinin urea total bilirubin treat group relat control plasma total cholesterol hdlcholesterol ldlcholesterol triglycerid also increas signific treat group relat control also hepat mda level increas signific all treat group howev hepat sod catalas gst activ were signific reduc lfxtreat anim moreov gsh ascorb acid level were signific decreas lfxtreat group relat control conclus three dose levofloxacin deplet antioxid defens system induc oxid stress hepat renal dysfunct rat

Ebenezer Tunde Olayinka

Ayokanmi Ore

Olaniyi Solomon Ola

Influence of Different Doses of Levofloxacin on Antioxidant Defense Systems and Markers of Renal and Hepatic Dysfunctions in Rats

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Advances in Toxicology

Advances in Toxicology