Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury

Figure 2

Mechanism of passive DNA demethylation. De novo methyltransferase 1 (DNMT1) is required to maintain the methylation pattern through successive replication; however, during reduced activity or in the absence of the maintenance DNA methyltransferase (DNMT1), there occurs progressive dilution of 5-methylcytosine (5mC) leading to the formation of unmethylated DNA.