Review Article
Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Table 1
Role of the methyl-binding domain protein family.
| MBD family | Binding activity | Implication | Reference |
| MeCP2 | Binds to methyl CpG with an adjacent stretch of AT-rich nucleotide | Repression of transcriptional activity | [80] | MBD1 | Binds to methyl CpG via methyl-binding domain | Gene silencing during DNA replication | [75] | MBD2 | Binds to methyl CpG | Repression of transcriptional activity | [85] | MBD3 | Low binding/incapable of binding to methyl CpG | Subunit of NuRD corepressor complex and acts as a transcriptional repressor | [86] | MBD4 | Binds to methyl CpG and T:G mismatches at methyl CpG sites | Catalyses the removal of T and U paired with G within CpG sites | [87] |
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