MCMs in Cancer: Prognostic Potential and Mechanisms

Figure 1

MCMs play essential roles in DNA replication initiation. During the G1 phase, ORC and Cdc6 bind to condensed chromatin in advance and recruit MCM2-7 double hexamer and Cdt1 to form OCCM intermediate. During the S phase, ORC and Cdc6 exit via Cdk-dependent phosphorylation and Cdt1 exits via geminin-dependent ubiquitination. The double hexamer separates and forms CMG complexes separately. GINS and CDC45 as well as other initiation factors interact with MCM2-7 hexamer and trigger DNA unwinding [3, 6, 7].