B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus

Figure 5

Germinal center (GC) changing a primary lymphoid follicle (LF) into a secondary LF. The GC is surrounded by the mantle zone, which is comprised of the light and dark zone, and populated by mature B (Bm) cells evolving from Bm1 in the T cell area through plasma cells that come back to the bone marrow.