Review Article
B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus
Table 1
Characteristics of primary B cell subsets and their progenitors.
| Differentiation | Subset | Surface phenotype |
| Progenitor subsets (bone marrow) | Pro-B | B220loCD43+ | | | AA4.1+ | | Pre-B | B220loCD43−, AA4.1+preBcR+ | | Immature (23−) | B220lo, sIgM+, sIgD−, CD23− | | Immature (23+) | CD19+, B220+, sIgM+, sIgD−, CD23+ | Transitional subsets (spleen) | T1 | IgMhiCD23−, B220intAA4.1+ | | T2 | IgMhiCD23+, B220+AA4.1+ | | T3 | IgMloCD23+, B220+AA4.1+ | Mature primary subsets | Follicular zone | IgMloCD23+, B220hiAA4.1− | | Marginal zone | CD19+IgMhiIgDlo CD23+ CD21+ | | B1 | CD43+ CD23− CD5+ | T-independent responses | Early antibody-forming cells/short-lived plasma cells | B220loCD19+slg+iclghi | T-dependent responses | Early antibody-forming cells/short-lived plasma cells | B220loCD19+slg+iclghi | | Germinal center | B220+CD19+GL7+ | | Long-lived plasma cells | B220loslg−iclg+ | | Memory | B220+slg+IgD− | Natural antibodies | Peritoneal B1a and B1b | CD43+ CD23− CD5+ |
|
|