|
Gene | Functional evaluation | Phenotype | Reference |
|
acvr1 | Laser thrombosis | Hemorrhagic/Prolonged TTO | [36, 37] |
ift122 | Laser thrombosis | Hemorrhagic/Prolonged TTO | [36, 37] |
poldip2 | Laser thrombosis | Hemorrhagic/Prolonged TTO | [36, 37] |
ripk5 | Laser thrombosis | Hemorrhagic/Prolonged TTO | [36, 37] |
mlck1a | Laser thrombosis | Prolonged TTO | [39] |
bambi | Laser thrombosis | Prolonged TTA/reduced thrombus surface area | [11] |
lrrc32 | Laser thrombosis | Prolonged TTA/Reduced TSA | [11] |
dcbld2 | Laser thrombosis | Increased TSA | [11] |
esam | Laser thrombosis | Increased thrombus size | [11] |
prkca (PKC ) | Laser thrombosis | Reduced TSA | [40] |
prkcb (PKC ) | Laser thrombosis | Reduced TSA | [40] |
itga2b (CD41) | Laser thrombosis/thrombocyte aggregation assays | Reduced TSA/Prolonged TTO/no aggregation of thrombocytes | [11, 41] |
scl | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [48] |
c-mpl | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [48] |
runx1 | Whole mount in situ hybridization/immunostaining | Accumulation of hematopoietic progenitors | [52] |
miR-126/c-myb | Thrombocyte formation | Decrease in CD41 : EGFP+ thrombocytes in a double transgenic reporter line Tg (cd41 : EGFP) : Tg (gata1 : dsRed) | [55] |
fog1 | Thrombocyte formation | Failure to generate eGFP+ cells in CD41-GFP transgenic zebrafish line | [56] |
mastl | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [58] |
march2 | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [59] |
max | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [59] |
smox | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [59] |
pttg11p | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [59] |
emilin1 | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [59] |
sufu | Thrombocyte formation | Reduction in GFP+ cells in CD41-GFP transgenic zebrafish line | [59] |
arhgef3 | Thrombocyte formation | Absence of GFP+ cells in CD41-GFP transgenic zebrafish line | [60] |
ak3 | Thrombocyte formation | Absence of GFP+ cells in CD41-GFP transgenic zebrafish line | [60] |
rnf45 | Thrombocyte formation | Absence of GFP+ cells in CD41-GFP transgenic zebrafish line | [60] |
jmjd1c | Thrombocyte formation | Absence of GFP+ cells in CD41-GFP transgenic zebrafish line | [60] |
tpma | Thrombocyte formation | Absence of GFP+ cells in CD41-GFP transgenic zebrafish line | [60] |
nbeal2 | Thrombocyte formation | Abrogation of thrombocyte formation | [61] |
rgs18 | Thrombocyte formation | Thrombocytopenia | [62] |
|