Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update

Table 5

Dosages of administrations of antifungal agents for empirical treatment of febrile neutropenia.

Antifungal	Doses
Fluconazole	400 mg/24 h IV/PO
Itraconazole	400 mg/24 h PO
Voriconazole	6 mg/kg every 12 h × 2 doses, then 4 mg/kg every 12 h; 200 mg/12 h PO
Posaconazole	Prophylaxis: 200 mg PO every 8 h
Caspofungin	70 mg IV initial doses, then 50 mg/24 h IV
Micafungin	100 mg/24 h IV for candidemia and 50 mg/24 h IV as prophylaxis; 150 mg/24 h IV for Aspergillus spp. infection
Anidulafungin	200 mg IV initial doses, then 100 mg/24 h IV