Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence
Figure 4
Effects of ethanol concentration on ethanol intake (mL) and the dose of ethanol (g/kg) consumed under home cage () and operant () self-administration procedures. Filled circles represent voluntary home cage ethanol intake, whereas unfilled circles represent operant ethanol intake under a fixed ratio (FR) 10 schedule of reinforcement. The points and vertical lines above “W” indicate the means ± standard error of the mean (SEM) for sessions in which water was available (control). The points with vertical lines in the concentration-effect data indicate the mean ± SEM for each ethanol concentration. The points without vertical lines indicate instances in which the SEM is encompassed by the point.
