Integrating TRPV1 Receptor Function with Capsaicin Psychophysics

Figure 2

Schematic diagram that illustrates key structural features of TRPV1 control and regulation of channel activity and ion transport. (a) Each TRPV1 subunit is a 95 kDa protein that contains six transmembrane domains, a pore region between the fifth and sixth transmembrane domains, and extended intracellular N- and C-terminal tails. Modified from Bevan et al. [33]. Vanilloid binding site from Yang et al. [32]. (b) Protein domains of canonical TRPV1 receptor (human TRPV1 receptor contains 839 amino acid residues). Blue columns represent N-terminal ankyrin repeats, and orange column represents the cytosolic linker domain. The six numbered green columns represent transmembrane domain regions of the receptor, and light yellow column represents the alpha helical domain of the pore-forming region found between transmembrane domains 5 and 6. The red column represents the cytosolic TRP domain, and the two brown columns represent putative C-terminal PIP₂ binding domains. Horizontal line represents the linear sequence of amino acids from the N-terminus to the C-terminus. Modified from Liao et al. [43].

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