Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes

Figure 4

Prediction profiler (4(a)) and standard Pareto plot (4(b)) illustrating the effects HPMC HPMC E 15 (X₁) and PEG 400 (X₂) on thickness, disintegration time, folding endurance, and tensile strength. The black lines denote the prediction trace; the dotted perpendicular red line corresponds to the current concentration of factor; and the value in red on vertical axis is predicted response based on the current concentration of factor.

(a) Prediction profiler

(b) Pareto plot