Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes

Table 4

ANOVA result (P value) of each response (thickness, folding endurance, disintegration time, and tensile strength).

Response	P value	R square	R square Adjusted
Thickness (mm)	<0.0001	0.98	0.52
Folding endurance (no)	0.016	0.85	0.57
Disintegration time (s)	0.0011	0.95	0.91
Tensile Strength (g)	0.0003	0.97	0.64

The bold and italic fonts are indicating the significance of each model. The P value < 0.01 and R square more than 0.6 means very good fit models indicated as bold font, P value < 0.05 and R square value in between 0.4 and 0.6 means good fit models indicated as italic font.