Research Article
Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes
Table 5
Data represents the stability testing parameters of optimized formulation (F6) at accelerated conditions.
| Sr. | Evaluation | 0 days | 15 days storage | 30 days storage | 60 days storage | 90 days | No. | Parameters | storage | storage |
| 1 | Physical appearance | Transparent white | Transparent white | Transparent white | Transparent white | Transparent white | 2 | Disintegration time (s) | 28 ± 2.9 | 26 ± 1.3 | 26 ± 3.5 | 25 ± 2.8 | 23 ± 5.1 | 3 | Folding endurance | 295 ± 2.28 | 291 ± 3.92 | 289 ± 6.42 | 281 ± 2.97 | 278 ± 5.57 | 4 | Drug content (%) | 98.97 ± 3.27 | 97.65 ± 2.71 | 96.14 ± 1.68 | 95.52 ± 3.82 | 95.09 ± 2.76 |
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