Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes

Table 5

Data represents the stability testing parameters of optimized formulation (F6) at accelerated conditions.

Sr.	Evaluation	0 days	15 days storage	30 days storage	60 days storage	90 days
No.	Parameters	storage				storage
1	Physical appearance	Transparent white	Transparent white	Transparent white	Transparent white	Transparent white
2	Disintegration time (s)	28 ± 2.9	26 ± 1.3	26 ± 3.5	25 ± 2.8	23 ± 5.1
3	Folding endurance	295 ± 2.28	291 ± 3.92	289 ± 6.42	281 ± 2.97	278 ± 5.57
4	Drug content (%)	98.97 ± 3.27	97.65 ± 2.71	96.14 ± 1.68	95.52 ± 3.82	95.09 ± 2.76