Tenofovir Nephrotoxicity: 2011 Update

Table 3

Predictors of significant renal function decline.

Preexisting renal impairment
Older age
Advanced HIV disease
Vasculometabolic disease
Concomitant use of nephrotoxic drugs or protease inhibitors
Low body weight
ABCC2 gene (encoding the outward tenofovir transporter MRP-2) polymorphisms