Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults
Table 2
Pharmacokinetic parameters and comparisons during tenofovir and emtricitabine plus efavirenz administration in the fasting (Day 1) and fed (Day 8) states.
Parameter
GM (95% CI)
GMR (90% CI)
Fasting*
Fed
Fed/Fasting
(ng/mL)
169 (137–255)
175 (136–275)
1.04 (0.84–1.27)
Tenofovir
(ng·h/mL)
1316 (1117–1748)
1568 (1369–2032)
1.19 (1.10–1.29)
(ng/mL)
27 (23–39)
27 (23–34)
0.99 (0.82–1.19)
(L/h)
186 (168–231)
156 (139–198)
0.84 (0.78–0.91)
(ng/mL)
1043 (935–1233)
870 (789–1016)
0.83 (0.76–0.92)
Emtricitabine
(ng·h/mL)
7029 (6300–8313)
6115 (5642–6846)
0.87 (0.78–0.97)
(ng/mL)
67 (57–92)
61 (53–81)
0.91 (0.73–1.14)
(L/h)
28 (26–33)
33 (30–37)
0.89 (0.80–0.99)
(ng/mL)
3128 (2678–4203)
4611 (3961–6037)
1.47 (1.24–1.75)
Efavirenz
(ng·h/mL)
46299 (37411–69475)
52194 (41827–76643)
1.13 (1.03–1.23)
(ng/mL)
1395 (1082–2335)
1408 (1073–2448)
1.01 (0.91–1.11)
(L/h)
13 (11.6–17.3)
12 (10.5–14.4)
0.89 (0.81–0.97)
GM: geometric means; GMR: geometric mean ratio; CI: confidence intervals, : maximum concentration; : concentration 24 hours after dosing; : area under the concentration-time curve; CL/F: clearance.
*reference.
