A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice

<div>The mechanism of disulfiram activation of HIV transcription. Disulfiram activates the PKB/Akt signalling pathway by depleting PTEN (see Doyon et al. [<a href="/journals/art/2017/8239428/#B24">25</a>]).</div>

AIDS Research and Treatment

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Figure 1: A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice 

Figure 1 | A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice 