Review Article
Human Herpesviridae Methods of Natural Killer Cell Evasion
Table 1
Summary of known interactions between NK cell receptors, ligands, and herpesvirus immunoevasins.
| Major receptors | Ligand | Virus | Immunoevasin | Mechanism | References |
| Activating | | | | | |
| |
MICA | HCMV | UL142 | Internal retention | [68, 69] | | KSHV | K5 | Ubiquitination/sequestration | [70, 71] | | HSV | ? | ? | [72, 73] | | HHV-7 | U21 | ? | [74] |
| | | HCMV | UL16 | Internal retention | [22, 75–77] | | | HCMV | miR-UL112 | Translational downregulation | [78] | NKG2D | | KSHV | K5 | Ubiquitination/sequestration | [70, 71] | | MICB | KSHV | miRK12-7 | Translational downregulation | [79] | | | HSV | ? | ? | [72, 73] | | | EBV | miR-BART2-5p | Translational downregulation | [79] | | | HHV-7 | U21 | ? | [74] |
| | | HCMV | UL16 | Internal retention | [22, 75–77] | | ULBP1–4 | HSV | ? | ? | [72] | | | HHV-7 | U21 | Lysosomal degradation | [74] |
| NCRs | AICL | KSHV | K5 | | [71] |
| DNAM-1 | PVR | ? | ? | | | CD112 | ? | ? | | |
| Inhibitory | | | | | |
| | | HCMV | UL18 | MHC-I homologue | [80, 81] | | | HCMV | UL40 | Signal prolongation | [82–84] | | | HCMV | US2, US3, US6, US11 | Retention/degradation | [63, 67] | | | KSHV | K5, K3 | Endocytosis | [85–87] | | | HSV | ICP47 | TAP interference | [88–90] | LIR-1, KIRs, CD94/NKG2A | MHC-I | EBV | vIL-10 | IL-10 homolog | [91] | | | EBV | BNLF2a | TAP interference | [92, 93] | | | EBV | BILF1 | Endocytosis/degradation | [94] | | | HHV-6 | U21 analogues | Lysosomal degradation | [95] | | | HHV-7 | U21 | Lysosomal degradation | [96–98] | | | VZV | ORF66 | Internal retention | [99, 100] |
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