|
Product | Plant host(s) | Importance | References |
|
Human pharmaceutical proteins | | | |
Human interferon-α | Turnip | First recombinant plant-derived pharmaceutical proteins. | [7] |
Human serum albumin | Tobacco, potato | Plant-derived proteins identical to the authentic human proteins. | [9] |
|
Antibodies | | | |
Mouse immunoglobulin | Tobacco | First plant-derived antibody showing the ability of plants to assemble heterologous biomolecules. | [8] |
Antibody against hepatitis B | Tobacco | First commercialized plant-derived antibody used for vaccine purification in Cuba. | [10] |
Antibody against Streptococcus mutans (CaroRx) | Tobacco | EU-approved medical device for prevention of tooth decay. | [6, 11] |
|
Industrial and agricultural recombinant enzymes | | | |
Avidin | Maize | Plant-derived products on the market. | [12] |
β-glucuronidase | Maize | [13] |
Trypsin | Maize | [14] |
|
Vaccine antigens- human use | | | |
Hepatitis B antigen | Tobacco | Plant-made HBsAg particles antigenically and physically similar to HBsAg particles derived from human serum and recombinant yeast. | [15] |
Lettuce, lupin | Specific antibody responses in human volunteers fed with transgenic lettuce. | [16] |
Potato | Increased specific serum immune response when given orally as a booster to vaccinated human volunteers. | [17] |
Escherichia coli LT-B | Potato | First proof of concept for edible plant-derived vaccines that conferred protection to mice upon oral feeding. | [18] |
Maize | Specific serum and mucosal antibody responses in human volunteers ingested transgenic corn germ meal. | [19] |
Norwalk virus | Tobacco, potato | Specific serum and mucosal antibody responses in mice fed orally with transgenic plants. Phase I clinical trials completed. | [20] |
|
Vaccine antigens- veterinary use | | | |
Newcastle disease virus HN proteins | Tobacco suspension cell culture | First USDA-approved plant-derived veterinary vaccine. | [21] |
|