Review Article
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
Table 3
Some important enzymes and their therapeutic importance.
| Enzyme | Reaction | Use | Sources | References |
| Asparaginase | L-Asparagine H2O→L-aspartate + NH3 | Leukaemia | E. coli | [82, 83] | Collagenase | Collagen hydrolysis | Skin ulcers | C. perfringens | [84] | Glutaminase | L-Glutamine H2O→L-glutamate + NH3 | Leukaemia | E. coli SFL-1 | [85, 86] | Lysozyme | Bacterial cell wall hydrolysis | Antibiotic | Homo sapiens | [87, 88] | Ribonuclease | RNA hydrolysis | Antiviral | Yeast and bacteriophages | [89, 90] | Streptokinase | Plasminogen→plasmin | Blood clots | Streptococci sp. | [91] | Trypsin | Protein hydrolysis | Inflammation | Homosapiens and other vertebrates | [92] | Uricase | Urate + O2→ allantoin | Gout | A. flavus | [93, 94] | Urokinase | Plasminogen→plasmin | Blood clots | Bacillus subtilis | [95, 96] | -Lactamase | -Lactam ring hydrolysis | Antibiotic resistance | Citrobacter freundii,
Serratia marcescens, and
Klebsiella pneumonia | [97] | Penicillin acylase | Binding the rings of benzylpenicillin (penicillin G) and phenoxymethylpenicillin (penicillin V) | Penicillin production/broad spectrum antibiotic production | Penicillium sp. | [98] |
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