Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

Figure 3

Summary of mechanisms of action of H. erinaceus mycelia enriched with erinacines in dementia. Primary alterations are possible contributors and drivers in the pathogenesis of Alzheimer’s disease. Secondary alterations include increased amyloid precursor protein intracellular domain (AICD) and accumulation of Aβ, leading to neuroinflammation. Finally, decreased neurogenesis and increased neurodegeneration can cause deficits in activities of daily living. The red dashed lines indicate potential mechanisms of H. erinaceus mycelia-attenuated pathological and behavioral changes in stroke, Parkinson’s disease, and Alzheimer’s disease.