Review Article
Alterations of the Erythrocyte Membrane during Sepsis
Table 1
Main modifications of the RBC membrane observed during sepsis.
| Membrane components | Model | Modifications reported | Effects | References |
| Proteins | Human RBCs | Membrane glycophorin A content increased during sepsis | Desialylation facilitates glycophorin A fixation | [9] | Human serum of patients with meningococcemia | No changes in serum glycophorin A during the first 36 hours | | [10] | Mice RBCs with sepsis induced by caecal ligature and perforation | Increased band 3/α-spectrin ratio | Associated altered RBC deformability | [11] | | Phosphorylation of the band 3 and anion transporter capacity | No effects on anion transporter capacity | [12] | Human RBCs | Decreased RBC proteins in septic and non-septic patients | No difference between septic and nonseptic patients | [13] |
| Lipids | Human RBCs | Increased membrane phosphatidylserine exposition | Increased entry of calcium → increased eryptosis ? | [14] | Human RBCs | Increased membrane lipid peroxidation | Modifications of RBC lipid organization | [15] | Rat RBCs | Controversial results on membrane lipid peroxidation | Effects on membrane fluidity? | [16, 17] |
| Carbohydrates | Human RBCs | Decreased sialic acid membrane content | Inverse relationship between spherical shape and decreased sialic acid membrane content. Stimulation of RBC glycolysis (increased lactate, 2,3-diphosphoglycerate) | [9] |
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