Review Article
The Role of Antifungals in Pediatric Critical Care Invasive Fungal Infections
Table 1
United States Food and Drug Administration (USFDA) approval timeline of antifungal agents [
13ā
15].
| Year of approval | Name of the antifungal agent |
| 1958 | Amphotericin B deoxycholate | 1973 | 5-Flucytosine | 1981 | Ketoconazole | 1990 | Fluconazole | 1992 | Itraconazole (oral suspension in 1997; intravenous form in 1999) | 1995 | Amphotericin B lipid complex | 1996 | Amphotericin B colloidal dispersion | 1997 | Liposomal amphotericin B | 2001 | Caspofungin | 2002 | Voriconazole | 2005 | Micafungin | 2006 | Anidulafungin | 2006 | Posaconazole (delayed release of tablet in 2013; intravenous form in 2014) | 2015 | Isavuconazole (Isavuconazonium) (oral and intravenous) |
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