The Role of Antifungals in Pediatric Critical Care Invasive Fungal Infections

Table 1

United States Food and Drug Administration (USFDA) approval timeline of antifungal agents [13–15].

Year of approval	Name of the antifungal agent
1958	Amphotericin B deoxycholate
1973	5-Flucytosine
1981	Ketoconazole
1990	Fluconazole
1992	Itraconazole (oral suspension in 1997; intravenous form in 1999)
1995	Amphotericin B lipid complex
1996	Amphotericin B colloidal dispersion
1997	Liposomal amphotericin B
2001	Caspofungin
2002	Voriconazole
2005	Micafungin
2006	Anidulafungin
2006	Posaconazole (delayed release of tablet in 2013; intravenous form in 2014)
2015	Isavuconazole (Isavuconazonium) (oral and intravenous)