The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture

Table 5

Comparison of ICAM-1 mrna expression levels between groups.

Comparison Groups	P Value
Control x Low Dose Pitavastatin	0.398
Control x High Dose Pitavastatin	0.432
Control x TNF-α	0.001
Control x Low Dose Pitavastatin + TNF-α	0.001
Control x High Dose Pitavastatin + TNF-α	0.001
Control x DMSO	0.001
Low Dose Pitavastatin x High Dose Pitavastatin	1.000
Low Dose Pitavastatin x TNF-α	0.001
Low Dose Pitavastatin x Low Dose Pitavastatin + TNF-α	0.001
Low Dose Pitavastatin x High Dose Pitavastatin + TNF-α	0.001
Low Dose Pitavastatin x DMSO	0.001
High Dose Pitavastatin x TNF-α	0.002
High Dose Pitavastatin x Low Dose Pitavastatin + TNF-α	0.002
High Dose Pitavastatin x High Dose Pitavastatin + TNF-α	0.002
High Dose Pitavastatin x DMSO	0.002
Low Dose Pitavastatin + TNF-αx TNF-α	0.001
Low Dose Pitavastatin + TNF-αx High Dose Pitavastatin + TNF-α	0.001
Low Dose Pitavastatin + TNF-αx DMSO	0.001
High Dose Pitavastatin + TNF-αx TNF-α	0.001
High Dose Pitavastatin + TNF-αx DMSO	0.001
TNF-α x DMSO	0.001

ICAM-1, intercellular adhesion molecule-1; TNF-α, tumor necrosis factor-α; DMSO, dimethyl sulfoxide.