LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model

Figure 1

Medical therapy protocol of heart failure (HF)-MI rats. Rats that survived one week after MI created were randomly assigned to receive vehicle, enalapril, or LCZ696 therapy. After 4-week medical therapy, HF-MI rats received electrophysiological (EP) exams to test ventricular arrhythmia (VA) inducibility and then were sacrificed for protein analyses. Sham rats were subjected to EP exams and protein analyses without medical therapy.