LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model

<p>(a) Action potential generation associated ion channel proteins test in this study. (b) Summarized diagram of the effects of LCZ696 therapy on the HF-MI rat model. APD, action potential duration; <span class="nowrap"><svg height="11.5695pt" id="M23" style="vertical-align:-3.18152pt" version="1.1" viewbox="-0.0498162 -8.38798 11.3042 11.5695" width="11.3042pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M303 0V28C221 34 213 39 213 125V525C213 610 221 616 303 622V650H38V622C120 616 128 610 128 525V125C128 40 120 34 38 28V0H303Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.433,3.132)"><path d="M676 0V33C628 38 606 47 555 101S396 279 321 373C388 440 457 509 495 545C556 601 582 609 660 617V650H412V617L436 615C479 608 479 601 452 566C405 510 345 447 289 394C258 366 239 353 216 348V518C216 605 226 612 305 617V650H40V617C123 612 130 605 130 518V131C130 46 121 38 44 33V0H310V33C226 38 216 46 216 131V318C235 322 249 319 274 290C367 181 444 84 520 0H676Z"></path></g></svg>,</span> potassium current; <span class="nowrap"><svg height="11.6836pt" id="M24" style="vertical-align:-3.29562pt" version="1.1" viewbox="-0.0498162 -8.38798 15.8073 11.6836" width="15.8073pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M303 0V28C221 34 213 39 213 125V525C213 610 221 616 303 622V650H38V622C120 616 128 610 128 525V125C128 40 120 34 38 28V0H303Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.433,3.132)"><path d="M731 650H485V618C556 614 580 601 585 558C588 530 592 485 592 390V153H589L173 650H22V618C69 614 92 606 112 582C131 558 132 555 132 483V266C132 175 129 128 125 96C120 49 95 36 36 33V0H281V33C212 36 188 50 183 98C180 129 177 175 177 266V510H179L603 -9H638V390C638 483 640 530 644 561C649 602 674 615 731 618V650Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.066,3.132)"><path d="M442 39L431 68C420 63 406 57 394 57C377 57 359 71 359 118V301C359 353 349 393 314 424C291 443 261 451 230 451C171 438 107 401 79 381C59 366 46 355 46 340C46 316 72 295 91 295C106 295 117 303 122 319C131 350 139 371 152 384C163 397 178 404 197 404C246 404 281 365 281 293V278C260 262 186 232 124 213C69 194 41 161 41 112C41 47 92 -12 163 -12C195 -12 243 25 283 51C288 35 293 22 308 7C319 -4 339 -12 354 -12L442 39ZM281 87C262 68 226 51 199 51C169 51 129 74 129 126C129 162 151 181 190 198C211 208 259 229 281 240V87Z"></path></g></svg>,</span> sodium current; SERCA, sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase; SR, sarcoplasmic reticulum; RYR, ryanodine receptor.</p>

Cardiovascular Therapeutics

fig5

Figure 5

Figure 5: LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model 