LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model

Table 1

Echocardiographic, electrophysiological, and anatomic parameters.

Parameters	Sham	HF vehicle	HF LCZ696	HF enalapril	P value	P value	P value	P value
	(N = 6)	(N = 7)	(N = 9)	(N = 6)	V vs. S	L vs. V	E vs. V	L vs. E
Baseline LVEF (%)	NA	36.2 ± 6.9	36.9 ± 4.5	37.7 ± 2.8	NA	0.797	0.618	0.684
Post-Rx LVESD (mm)	3.9 ± 0.4	6.3 ± 0.8	5.3 ± 0.7	5.6 ± 1.3	<0.001	0.012	0.239	0.530
Post-Rx LVESV (μl)	153 ± 40	602 ± 202	367 ± 121	465 ± 299	<0.001	0.011	0.345	0.389
Post-Rx FS (%)	34.0 ± 3.2	14.5 ± 2.5	24.8 ± 2.3	20.1 ± 5.2	<0.001	<0.001	0.027	0.031
Post-Rx LVEF (%)	69.1 ± 4.0	38.5 ± 2.0	57.6 ± 5.5	46.7 ± 9.1	< 0.001	< 0.001	0.040	0.007
Body weight (g)	578 ± 43	562 ± 55	527 ± 20	500 ± 49	0.562	0.095	0.057	0.163
HW/BW ratio (%)	0.22 ± 0.04	0.30 ± 0.05	0.27 ± 0.02	0.30 ± 0.03	0.003	0.041	0.886	0.016
Heart weight (g)	1.29 ± 0.18	1.66 ± 0.25	1.45 ± 0.11	1.55 ± 0.18	0.008	0.058	0.396	0.237
Heart rate (BPM)	213 ± 34	210 ± 51	214 ± 28	224 ± 24	0.888	0.848	0.552	0.502
PR interval (ms)	50.7 ± 2.6	50.1 ± 5.7	50.9 ± 6.2	48.5 ± 4.4	0.825	0.817	0.577	0.444
QRS duration (ms)	39.7 ± 5.6	41.4 ± 6.2	42.5 ± 4.6	41.5 ± 2.0	0.575	0.709	0.979	0.631
Corrected QT (ms)	227 ± 13	260 ± 35	244 ± 25	253 ± 23	0.036	0.305	0.695	0.459
VERP (ms)	56.7 ± 5.2	65.7 ± 9.8	53.8 ± 5.2	60.0 ± 6.3	0.047	0.010	0.246	0.064
VA inducibility (%)	0 (0%)	7 (100%)	1 (11%)	4 (67%)	0.001	0.001	0.227	0.047

BPM, beats per minute; FS, fractional shortening; HW/BW, heart weight/body weight; HF, heart failure; NA, not available; Post-Rx, postmedical therapy (or before electrophysiological exam in the sham group); VA, ventricular tachyarrhythmia; VERP, ventricular effective refractory period.
Groups abbreviations: S, Sham; V, vehicle; L, LCZ696; E, enalapril.