Research Article
LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model
Table 1
Echocardiographic, electrophysiological, and anatomic parameters.
| Parameters | Sham | HF vehicle | HF LCZ696 | HF enalapril | P value | P value | P value | P value | (N = 6) | (N = 7) | (N = 9) | (N = 6) | V vs. S | L vs. V | E vs. V | L vs. E |
| Baseline LVEF (%) | NA | 36.2 ± 6.9 | 36.9 ± 4.5 | 37.7 ± 2.8 | NA | 0.797 | 0.618 | 0.684 | Post-Rx LVESD (mm) | 3.9 ± 0.4 | 6.3 ± 0.8 | 5.3 ± 0.7 | 5.6 ± 1.3 | <0.001 | 0.012 | 0.239 | 0.530 | Post-Rx LVESV (μl) | 153 ± 40 | 602 ± 202 | 367 ± 121 | 465 ± 299 | <0.001 | 0.011 | 0.345 | 0.389 | Post-Rx FS (%) | 34.0 ± 3.2 | 14.5 ± 2.5 | 24.8 ± 2.3 | 20.1 ± 5.2 | <0.001 | <0.001 | 0.027 | 0.031 | Post-Rx LVEF (%) | 69.1 ± 4.0 | 38.5 ± 2.0 | 57.6 ± 5.5 | 46.7 ± 9.1 | < 0.001 | < 0.001 | 0.040 | 0.007 | Body weight (g) | 578 ± 43 | 562 ± 55 | 527 ± 20 | 500 ± 49 | 0.562 | 0.095 | 0.057 | 0.163 | HW/BW ratio (%) | 0.22 ± 0.04 | 0.30 ± 0.05 | 0.27 ± 0.02 | 0.30 ± 0.03 | 0.003 | 0.041 | 0.886 | 0.016 | Heart weight (g) | 1.29 ± 0.18 | 1.66 ± 0.25 | 1.45 ± 0.11 | 1.55 ± 0.18 | 0.008 | 0.058 | 0.396 | 0.237 | Heart rate (BPM) | 213 ± 34 | 210 ± 51 | 214 ± 28 | 224 ± 24 | 0.888 | 0.848 | 0.552 | 0.502 | PR interval (ms) | 50.7 ± 2.6 | 50.1 ± 5.7 | 50.9 ± 6.2 | 48.5 ± 4.4 | 0.825 | 0.817 | 0.577 | 0.444 | QRS duration (ms) | 39.7 ± 5.6 | 41.4 ± 6.2 | 42.5 ± 4.6 | 41.5 ± 2.0 | 0.575 | 0.709 | 0.979 | 0.631 | Corrected QT (ms) | 227 ± 13 | 260 ± 35 | 244 ± 25 | 253 ± 23 | 0.036 | 0.305 | 0.695 | 0.459 | VERP (ms) | 56.7 ± 5.2 | 65.7 ± 9.8 | 53.8 ± 5.2 | 60.0 ± 6.3 | 0.047 | 0.010 | 0.246 | 0.064 | VA inducibility (%) | 0 (0%) | 7 (100%) | 1 (11%) | 4 (67%) | 0.001 | 0.001 | 0.227 | 0.047 |
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BPM, beats per minute; FS, fractional shortening; HW/BW, heart weight/body weight; HF, heart failure; NA, not available; Post-Rx, postmedical therapy (or before electrophysiological exam in the sham group); VA, ventricular tachyarrhythmia; VERP, ventricular effective refractory period. Groups abbreviations: S, Sham; V, vehicle; L, LCZ696; E, enalapril.
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