LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model

Table 2

Protein expression.

Protein expression	Sham	HF	HF	HF	P value	P value	P value	P value
		vehicle	LCZ696	enalapril	V vs. S	L vs. V	E vs. V	L cs E
	1.00 ± 0.32	0.62 ± 0.23	0.79 ± 0.27	0.62 ± 0.24	0.020	0.130	0.497	0.136
3.1	1.00 ± 0.45	0.87 ± 0.41	1.17 ± 0.28	1.18 ± 0.42	0.307	0.085	0.114	0.485
1.2	1.00 ± 0.34	0.94 ± 0.16	0.96 ± 0.38	1.11 ± 0.62	0.402	0.475	0.333	0.365
7.1 (KCNQ1)	1.00 ± 0.74	0.93 ± 0.65	1.15 ± 0.83	1.12 ± 0.78	0.437	0.316	0.335	0.474
4.3	1.00 ± 0.32	0.91 ± 0.49	1.07 ± 0.17	0.81 ± 0.19	0.349	0.227	0.326	0.016
ERG (KCNH2)	1.00 ± 0.32	0.48 ± 0.19	0.92 ± 0.48	0.65 ± 0.28	0.003	0.030	0.120	0.129
KCNE1 (MinK)	1.00 ± 0.20	0.74 ± 0.27	1.08 ± 0.25	0.77 ± 0.34	0.043	0.023	0.435	0.048
KCNE2 (MiRP1)	1.00 ± 0.43	0.56 ± 0.14	0.79 ± 0.26	0.74 ± 0.35	0.018	0.044	0.127	0.410
Cx34	1.00 ± 0.63	1.05 ± 0.54	1.23 ± 0.66	1.19 ± 0.77	0.448	0.304	0.354	0.465

Groups abbreviations: S, Sham; V, vehicle; L, LCZ696; E, enalapril. N = 6 for each group.