Cardiovascular Therapeutics

Review Article

Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials

Inconsistency revealed in the subgroup NMA node-splitting tests.


Outcomes of the NMAs	Groups	Inconsistency was observed between direct and indirect evidences in these comparisons

LDL-C	Group 1	Placebo vs. fluvastatin; atorvastatin vs. rosuvastatin; atorvastatin vs. lovastatin; rosuvastatin vs. lovastatin
	Group 2	Placebo vs. rosuvastatin
	Group 3	None (no indirect comparison involved)

HDL-C	Group 1	None (no indirect comparison involved)
	Group 2	Placebo vs. rosuvastatin
	Group 3	None (no indirect comparison involved)

TC	Group 1	None (no indirect comparison involved)
	Group 2	None (no indirect comparison involved)
	Group 3	None (no indirect comparison involved)

TG	Group 1	None (no indirect comparison involved)
	Group 2	None (no indirect comparison involved)
	Group 3	None (no indirect comparison involved)

ApoA1	Group 1	NA
	Group 2	NA
	Group 3	NA

ApoB	Group 1	NA
	Group 2	NA
	Group 3	NA

NA: too few articles included in the subgroup analysis, data contain no potential source of heterogeneity.