Extended Renal Artery Denervation Is Associated with Artery Wall Lesions and Acute Systemic and Pulmonary Hemodynamic Changes: A Sham-Controlled Experimental Study
Table 2
Hemodynamic changes in the RDN and SHAM groups.
RDN group ()
SHAM group ()
, between groups, when parameters were analyzed after procedures
A subgroup of RDN animals with MAP drop: delta in parameters after ablation, median [IQR],
, five RDN cases with MAP drop, comparison of parameters before and after ablation
Before RDN,
After RDN,
Before sham,
After sham,
HR (min-1)
0.24
3 [-2; 12]
0.34
sBP (mmHg)
0.03
-6 [-14; -6]
0.04
dBP (mmHg)
0.05
-7 [-9; -4]
0.14
MAP (mmHg)
0.04
-7 [-10; -6]
0.04
sPAP (mmHg)
0.24
-1 [-1; 0]
0.27
dPAP (mmHg)
0.82
-2 [-5; -1]
0.06
mPAP (mmHg)
0.48
-1 [-4; 0]
0.11
sRV (mmHg)
0.04
-1 [-3; 3]
0.89
dRV (mmHg)
0.48
0 [-1; 0]
0.18
mRV (mmHg)
0.31
-1 [-1; -1]
0.22
PWP (mmHg)
0.39
-1 [-2; 0]
0.47
RAP (mmHg)
0.24
-3 [-3; -2]
0.07
SVR ()
0.24
-252.9 [-591.7; 96.0]
0.22
PVR ()
†
†
0.06
-88.0 [-92.4; -36.5]
0.03
CO (l/min)
0.24
0.2 [-0.3; 0.5]
0.68
HR: heart rate; sBP: systolic blood pressure; dBP: diastolic blood pressure; MAP: mean arterial pressure; sPAP: systolic pulmonary artery pressure; dPAP: diastolic pulmonary artery pressure; mPAP: medium pulmonary artery pressure; sRV: systolic right ventricle pressure; dRV: diastolic right ventricle pressure; mRV: medium right ventricle pressure; PWP: pulmonary wedge pressure; RAP: right atrial pressure; SVR: systemic vascular resistance; PVR: pulmonary vascular resistance; CO: cardiac output. † in baseline parameters between the groups.
