Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
Table 1
Baseline characteristics of the participants.
VPZ group ()
PPI group ()
value VPZ versus PPI
RPZ group ()
value VPZ versus RPZ
Age (yrs)
58 (32–80)
60 (36–77)
0.7196
61 (36–77)
0.9299
Male
41/72 (57%)
40/69 (58%)
0.9019
35/59 (59%)
0.7838
Body mass index (kg/m2)
22.4 (17.9–30.7)
22.6 (16.1–37.8)
0.4780
22.7 (16.1–37.8)
0.3382
Smoking
17/70 (24%)
19/67 (28%)
0.5883
15/57 (26%)
0.7932
Drinking
22/72 (31%)
22/67 (33%)
0.7727
18/57 (32%)
0.9007
Comorbidities
Gastric ulcer
1/72 (1.4%)
1/69 (1.4%)
1.0000
1/59 (1.7%)
1.0000
Duodenal ulcer
2/72 (2.8%)
2/69 (2.9%)
1.0000
2/59 (3.4%)
1.0000
Diabetes
8/72 (11.1%)
2/69 (2.9%)
0.0976
2/59 (3.4%)
0.1838
Hypertension
14/72 (19.4%)
17/69 (24.6%)
0.4567
16/59 (27.1%)
0.2983
Hyperlipidemia
8/72 (11.1%)
14/69 (20.3%)
0.1333
14/59 (23.7%)
0.0546
AST (IU/L)
20
21
0.7424
21
0.3131
ALT (IU/L)
17
17
0.4114
17
0.1291
Creatinine (mg/dL)
0.78
0.78
0.6356
0.78
0.3345
Hemoglobin A1c (%)
5.6
5.6
0.1300
5.6
0.3101
Data are expressed as median (range) or number (percentage). Statistical analyses were conducted with the Mann–Whitney U test and chi-square test or Fisher’s exact test. VPZ group, treatment with vonoprazan, amoxicillin, and clarithromycin; PPI group, treatment with rabeprazole or lansoprazole, amoxicillin, and clarithromycin; RPZ group, treatment with rabeprazole, amoxicillin, and clarithromycin; AST, aspartate aminotransferase; ALT, alanine aminotransferase. , , , , , and .
