Research Article
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
Table 1
Baseline demographic, disease-related, and psychological characteristics of patients with IBD according to use of antidepressants.
| | Prescribed Antidepressants at Baseline (n = 54) | Not prescribed Antidepressants at Baseline (n = 288) | P value |
| Mean age in years (SD) | 47.1 (13.8) | 39.6 (16.2) | 0.001 |
| Mean duration of follow-up in days (SD) for each endpoint | | | | Glucocorticosteroid prescription or flare of disease activity | 648.3 (409) | 502.9 (361.8) | 0.02 | Escalation of medical therapy in response to uncontrolled disease activity | 664.0 (399.1) | 531.0 (345.3) | 0.03 | Hospitalisation due to disease activity (%) | 841.4 (284.1) | 733.2 (252.1) | 0.01 | Intestinal resection (%) | 861.4 (265.6) | 770.7 (218.1) | 0.02 |
| Female gender () | 47 (87.0) | 158 (54.9) | <0.001 |
| Caucasian ethnicity () | 51 (96.2) | 267 (93.7) | 0.47 |
| Married or co-habiting () | 27 (50.9) | 165 (58.3) | 0.32 |
| University/postgraduate () | 16 (29.6) | 102 (36.0) | 0.37 |
| Mean BMI (SD) | 28.0 (6.2) | 25.6 (5.3) | 0.01 |
| Tobacco user () | 14 (25.9) | 48 (16.8) | 0.11 |
| Alcohol user () | 31 (57.4) | 200 (69.9) | 0.07 |
| Crohn’s disease () | 20 (37.0) | 118 (41.0) | 0.59 |
| 5-ASA use () | 27 (50.0) | 124 (43.1) | 0.35 |
| Immunosuppressant use () | 16 (29.6) | 117 (40.6) | 0.13 |
| Biologic use () | 6 (11.1) | 63 (21.9) | 0.07 |
| Glucocorticosteroid use () | 5 (9.3) | 26 (9.0) | 0.96 |
| HBI/SCCAI <5 () | 23 (45.1) | 159 (58.7) | 0.07 |
| HADS anxiety scores at baseline () | | | | Normal | 16 (29.6) | 167 (58.6) | | Borderline abnormal | 10 (18.5) | 10 (18.5) | | Abnormal | 28 (51.9) | 69 (24.2) | <0.001 |
| HADS depression scores at baseline () | | | | Normal | 29 (53.7) | 230 (80.1) | | Borderline abnormal | 11 (20.4) | 35 (12.2) | | Abnormal | 14 (25.9) | 22 (7.7) | <0.001 |
| PHQ-15 somatisation scores at baseline () | | | | Mild | 0 (0) | 50 (18.8) | | Low | 8 (15.7) | 83 (31.2) | | Medium | 20 (39.2) | 78 (29.3) | | High | 23 (45.1) | 55 (20.7) | <0.001 |
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Independent samples t-test for continuous data and χ2 for comparison of categorical data. |