The Effect of Antidepressants on the Course of Inflammatory Bowel Disease

Table 4

Effect of SSRI use on subsequent development of IBD activity and according to anxiety and depression scores at baseline.

	SSRI Use: All Patients			SSRI Use: Normal Anxiety and Depression Scores at Baseline			SSRI use: Abnormal Anxiety or Depression Scores at Baseline
	No	Yes	P Value	No	Yes	P value	No	Yes	P value
Glucocorticosteroid prescription or flare of disease activity ()	121/279; (43.4)	14/33; (42.4)	0.92	82/203; (40.4)	6/13; (46.2)	0.68	38/73; (52.1)	8/20; (40.0)	0.34
Escalation of medical therapy in response to uncontrolled disease activity ()	120/279; (43.0)	10/33; (30.3)	0.16	85/203; (41.9)	5/13; (38.5)	0.81	34/73; (46.6)	5/20; (25.0)	0.08
Hospitalisation due to disease activity ()	38/279; (13.6)	2/33; (6.1)	0.22	26/203; (12.8)	2/13; (15.4)	0.79	12/73; (16.4)	0/20; (0)	0.05
Intestinal resection ()	15/279; (5.4)	2/33; (6.1)	0.87	8/203; (3.9)	2/13; (15.4)	0.06	7/73; (9.6)	0/20; (0)	0.15
Any adverse outcome ()	148/279; (53.0)	14/33; (42.4)	0.25	102/203; (50.2)	6/13; (46.2)	0.78	45/73; (61.6)	8/20; (40.0)	0.08