Research Article
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
Table 4
Effect of SSRI use on subsequent development of IBD activity and according to anxiety and depression scores at baseline.
| ā | SSRI Use: All Patients | SSRI Use: Normal Anxiety and Depression Scores at Baseline | SSRI use: Abnormal Anxiety or Depression Scores at Baseline | No | Yes | P Value | No | Yes | P value | No | Yes | P value |
| Glucocorticosteroid prescription or flare of disease activity () | 121/279 (43.4) | 14/33 (42.4) | 0.92 | 82/203 (40.4) | 6/13 (46.2) | 0.68 | 38/73 (52.1) | 8/20 (40.0) | 0.34 |
| Escalation of medical therapy in response to uncontrolled disease activity () | 120/279 (43.0) | 10/33 (30.3) | 0.16 | 85/203 (41.9) | 5/13 (38.5) | 0.81 | 34/73 (46.6) | 5/20 (25.0) | 0.08 |
| Hospitalisation due to disease activity () | 38/279 (13.6) | 2/33 (6.1) | 0.22 | 26/203 (12.8) | 2/13 (15.4) | 0.79 | 12/73 (16.4) | 0/20 (0) | 0.05 |
| Intestinal resection () | 15/279 (5.4) | 2/33 (6.1) | 0.87 | 8/203 (3.9) | 2/13 (15.4) | 0.06 | 7/73 (9.6) | 0/20 (0) | 0.15 |
| Any adverse outcome () | 148/279 (53.0) | 14/33 (42.4) | 0.25 | 102/203 (50.2) | 6/13 (46.2) | 0.78 | 45/73 (61.6) | 8/20 (40.0) | 0.08 |
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