Alleviation of Anxiety/Depressive-Like Behaviors and Improvement of Cognitive Functions by Lactobacillus plantarum WLPL04 in Chronically Stressed Mice

Figure 2

L. plantarum WLPL04 treatment reduces anxiety-like behaviors in chronically stressed mice. (a) The moving trajectory of the three groups of mice in the open-field test. (b) Chronically stressed mice exhibit significantly ( < 0.01) less time in the central area of the open field, and such behavioral phenotype is alleviated by the L. plantarum WLPL04 treatment. Chronically stressed mice have spent (c) significantly ( < 0.01) less time and (d) significantly ( < 0.05) fewer entries into the open arms in the elevated plus maze test, and such behavioral phenotypes are alleviated by the L. plantarum WLPL04 treatment. (e) Chronically stressed mice demonstrate significantly ( < 0.01) longer immobility time, and such behavioral phenotype is alleviated by the L. plantarum WLPL04 treatment. n = 7 – 12 mice per group.

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