Investigating the Lymphatic System by Dual-Color Elemental Mass Spectrometry Imaging

Figure 2

Tm-DOTMA as contrast agent for the investigation of lymphatic systems. Microscopic (a) phase contrast and (b) bright field images of a the left iliac lymph node after administration of Gd-DO3A-butrol and Tm-DOTMA in the left hind paw of a rat with corresponding LA-ICP-MS (c) Gd distribution and (d) Tm distribution. (e) Microscopic image of a lymph vessel with (f) corresponding LA-ICP-MS Tm distribution after administration of Tm-DOTMA in the left hind paw. Scale bar represents 500 µm.

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