Labelling of Y- and Lu-DOTA-Bioconjugates for Targeted Radionuclide Therapy: A Comparison among Manual, Semiautomated, and Fully Automated Synthesis

Table 3

Evaluation of radiochemical purity of ⁹⁰Y- and ¹⁷⁷Lu-PSMA-617 preparations performed by the automated automatic synthesizer ML Eazy.

	^90Y-PSMA-617	^177Lu-PSMA-617
Syntheses failed	0/5	0/5
Uncompliant preparations (RCP < 97%)	0/5	0/5
TLC
Free-radionuclide	0.2	0.3
Hydrolysed products	0.1	0.1
Labelled product	99.7	99.6
HPLC
Free radionuclide + hydrolysed products	0.5	0.3
By-products	1.0	0.2
Labelled product	98.5	99.5