Toward the Optimization of (+)-[¹¹C]PHNO Synthesis: Time Reduction and Process Validation

Figure 6

(a) Comparison of the synthesis duration of (+)-[¹¹C]PHNO synthesis at room temperature (n = 16) and according to our previously published method including heating and cooling (n = 9). (b) Influence of the temperature at LAH addition on the isolated radiochemical yield not corrected for decay (22°C: n = 16, −15°C: n = 9, −40°C: n = 3).

(a)

(b)