Research Article
Is Subcutaneous Route an Alternative to Intravenous Route for Mouse Contrast-Enhanced Magnetic Resonance Imaging at 1.5 T?
Table 3
TTP and semiquantitative uptake and washout values extracted from DCE analysis.
| | Contrast agent | Fit-curves analysis | Intravenous | Subcutaneous | | Liver | Muscle | Vein | Liver | Muscle | Vein |
| | Gd-DOTA (Dotarem) | Uptake constant time (min) | 1.1 | 1.1 | 1.1 | 37.0 | 26.3 | 17.5 | | Mean uptake | 1.1 | 24.4 | | (min) | | Washout constant time (min) | 80.0 | 58.5 | 81.3 | 75.8 | 61.0 | 120.4 | | Mean washout (min) | 71.9 | 79.4 | | Time to peak (TTP) | 4.9 | 4.8 | 5.0 | 51.1 | 39.0 | 40.0 | | (min) | | mean time to peak (mTTP) | 4.9 | 43.3 | | (min) | | mCNR (at mTTP) | 7.5 | 2.5 | 3.5 | 5.8 | 1.9 | 2.7 |
| | MS-325 (Vasovist) | Uptake constant time (min) | 1.1 | 1.1 | 1.1 | 19.6 | 24.4 | 20.4 | | Mean uptake | 1.1 | 21.3 | | (min) | | Washout constant time (min) | 144.9 | 114.9 | 169.5 | 140.9 | 106.4 | 126.6 | | Mean washout (min) | 143.1 | 120.5 | | Time to peak (TTP) | 5.9 | 5.3 | 5.1 | 44 | 47 | 44 | | (min) | | Mean time to peak (mTTP) | 5.4 | 45.0 | | (min) | | mCNR (at mTTP) | 10.5 | 9.4 | 20.1 | 10.6 | 13.6 | 18.9 |
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