Case Report
Treatment of Acute Tacrolimus Toxicity with Phenytoin in Solid Organ Transplant Recipients
Table 1
Summary of patients.
| | Patient number | Transplant type | Age race sex | Time since transplant (months) | Causative factor(s) | Clinical presentation | Baseline SCr (mg/dL) | Admit SCr (mg/dL)/% increase from baseline | Admit potassium (mEq/L) | FK level on admit (ng/mL) |
| | 1 | Liver | 53 W M | 20.8 | Atazanavir therapy, hepatitis C infection | Acute kidney injury, nausea, vomiting | 1.7 | 6.3/270% | 6.7 | >30 | | 2 | Heart | 57 AA F | 9.2 | Fluconazole therapy | Acute kidney injury, fever, chest pain | 1 | 7.3/630% | 6.2 | >30 | | 3 | Heart/kidney | 70 As M | 12.4 | Herbal supplements; disseminated Nocardia infection | Acute kidney injury, nausea, diarrhea | 0.8 | 4.2/425% | 6.1 | >30 | | 4 | Kidney | 58 W M | 5.5 | Voriconazole therapy, pseudomonas, and nocardia pneumonia | Acute kidney injury, fevers, shortness of breath | 2.1 | 3.5/67% | 6.4 | 23.7 |
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