Canadian Respiratory Journal

Research Article

Serum Levels of Epithelial-Derived Cytokines as Interleukin-25 and Thymic Stromal Lymphopoietin after a Single Dose of Mepolizumab in Patients with Severe Non-Allergic Eosinophilic Asthma: A Short Report

Table 1

Demographic and clinical characteristics of the study population.


	SNEA subjects

Number (n)	9
Sex (M/F)	5/4
Age (years)	53 ± 5.2
BMI (kg/m²)	28.9 ± 1.6
High-dose iCS + LABA	5
High-dose iCS + LABA + LAMA	3
High-dose iCS + LABA + theophylline	1

	At baseline visit	4 weeks after a single dose of mepolizumab
FEV₁ (l)	2.1 ± 0.5	2.6 ± 0.4
FEV₁ (% of predicted)	65.4 ± 8.8	76.4 ± 9.1
Blood eosinophil count (×10⁹/l)	0.55 ± 0.20	0.14 ± 0.04
FeNO (ppb)	32.3 ± 8.4	42.9 ± 12.6

F: female; M: male; FEV₁: forced expiratory volume in 1st second; FeNO: fractional exhaled nitric oxide; iCS: inhaled glucocorticosteroids; LABA: long-acting β-adrenoceptor agonists; LAMA: long‐acting muscarinic antagonists. Data are presented as the mean ± standard error of the mean. comparing with the baseline visit.