Determinants of Normal Left Atrial Volume in Heart Failure with Moderate-to-Severely Reduced Ejection Fraction

Table 2

Factors associated with a normal LAVi.

Variable	6-month interval			1-year interval
	OR	95% CI	value	OR	95% CI	value
Younger age	1.18	1.06–1.31	<0.01	1.22	1.06–1.42	<0.01
White race	7.43	0.90–61.52	0.06	5.62	0.55–57.49	0.15
ACE-I therapy	3.67	0.54–25.17	0.19	6.73	0.66–68.34	0.11
Decreased LVEDVi	1.04	0.99–1.08	0.11
Longer DT	1.02	1.00–1.04	0.03
E-to-A ratio				8.84	1.05–74.29	0.05

The model suggested that the following risk factors are associated with an increased probability of having a normal LAVi with 6-month interval and 1-year interval between baseline and follow-up TTEs: younger age, white race, being on ACE-I therapy, smaller LVEDVi, longer DT, and higher E-to-A ratio. The model predicted an area under the curve of 0.95 for the 6-month interval and 0.94 for the 1-year interval. ACE-I, angiotensin-converting enzyme inhibitor; LVEDVi, indexed left ventricular end-diastolic volume; DT, deceleration time; E-to-A ratio, early-to-late mitral inflow velocity ratio; LAVi, indexed left atrial volume.